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Characterization of gastrointestinal hemorrhage and prediction of mortality in Asian patients with alcoholic hepatitis
- Source :
- Journal of Gastroenterology and Hepatology. 31:814-821
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- BACKGROUND AND AIM Gastrointestinal bleeding (GIB) often accompanies alcoholic hepatitis (AH). The study aimed to investigate clinical characteristics of GIB in AH patients and to identify risk factors for mortality in AH patients with GIB. METHODS Data from 329 patients hospitalized with AH in a single center during 1999-2014 were retrospectively analyzed. Patients with AH were dichotomized into GIB and non-GIB groups. The GIB group was further divided into portal hypertensive bleeding (PHB) and non-PHB groups. Clinical characteristics and survival outcomes were compared between the groups. Risk factors for mortality were analyzed using Cox regression. RESULTS Among the 329 AH patients, 132 experienced GIB at admission or during hospitalization. The most common cause of GIB was an esophageal varix. The GIB group had worse survival outcomes than the non-GIB group (log-rank test, P = 0.034). The PHB group had worse survival outcomes than the non-PHB group (log-rank test, P = 0.001). On multivariate analysis, alcohol consumption, ascites, encephalopathy, infection, Maddrey's discriminant function, and the model for end-stage liver disease (MELD) score independently predicted mortality in the entire AH cohort. The MELD score (hazard ratio, 1.085; 95% confidence interval, 1.052-1.120; P
- Subjects :
- medicine.medical_specialty
Gastrointestinal bleeding
Hepatology
business.industry
Proportional hazards model
Hazard ratio
Gastroenterology
Alcoholic hepatitis
Retrospective cohort study
medicine.disease
03 medical and health sciences
0302 clinical medicine
Model for End-Stage Liver Disease
030220 oncology & carcinogenesis
Internal medicine
Medicine
030211 gastroenterology & hepatology
business
Survival rate
Cohort study
Subjects
Details
- ISSN :
- 08159319
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology and Hepatology
- Accession number :
- edsair.doi...........aa1dd7ca1d706214b9b162213239ebd8