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Cerebellar granuloprival and trans‐synaptic degeneration in a Chihuahua
- Source :
- Veterinary Record Case Reports. 8
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- An unusual form of cerebellocortical degeneration called cerebellar granuloprival degeneration was diagnosed in a four-month-old Chihuahua. The dog had a two-week history of progressive signs of cerebellar dysfunction, including a wide-based stance, intention tremors and bilateral absence of menace response without visual impairment. On MRI of the encephalon, a reduction in cerebellar size was detected. On histopathological examination, depletion of the cerebellar granule cell layer was observed, in addition to neuronal degeneration in the vestibular nuclei, reticular formation, red nucleus and internal laminae of the parietal and temporal cortices. A diagnosis of cerebellar granuloprival degeneration with trans-synaptic degeneration was made. To the authors’ knowledge, this is the first case report of cerebellar granuloprival degeneration in a Chihuahua and the first report of cerebellar granuloprival degeneration with trans-synaptic degeneration in a dog.
- Subjects :
- Pathology
medicine.medical_specialty
General Veterinary
040301 veterinary sciences
Red nucleus
business.industry
0402 animal and dairy science
04 agricultural and veterinary sciences
Degeneration (medical)
Reticular formation
Granule cell
040201 dairy & animal science
people.cause_of_death
0403 veterinary science
medicine.anatomical_structure
nervous system
Vestibular nuclei
medicine
Neuronal degeneration
people
business
Temporal Cortices
Cerebellar abiotrophy
Subjects
Details
- ISSN :
- 20526121
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Veterinary Record Case Reports
- Accession number :
- edsair.doi...........a9d945a6837df7f5e5711f9f013a230a