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Ontogenetic peculiarities of the effect of dantrolene and caffeine on the cardiac, respiratory and motor performance of intact and poisoned by physostigmine of rats
- Source :
- Reviews on Clinical Pharmacology and Drug Therapy. 18:139-148
- Publication Year :
- 2020
- Publisher :
- ECO-Vector LLC, 2020.
-
Abstract
- Activities of the somatomotor (MA), cardiovascular and respiratory systems were investigated in conditions of activation and blockade of ryanodine receptors (RyR) impaired cholinergic regulation in rat pups aged 3, 16 and 30 days. It was found that blockage of RyR by dantrolene has a negative chronotropic effect, the severity of which decreases with age, reduces the respiratory rate in rats on P3 and practically does not change in older animals. The amplitude of EMG and the power of motor bursts decreases in rats on P3-P16 and increases on P30. The duration of MA in the activity- rest cycle remains unchanged at P3 and decreases at P16-P30, which indicates a different change in the pattern of MA in rats of different ages after the blockade of RyR. Caffeine-induced activation of RyR is accompanied by an increase in heart rate and respiratory rate in rats on P30 and does not cause significant changes in these parameters on P3-P16. There has been an increase in all MA indices, especially in P3. Certain age-related regularities were revealed in the conditions of acetylcholinesterase inhibition by physostigmine, carried out against the background of RyR inhibition or activation. Maximum sensitivity to such effects was found in rats on P3. It was shown that in early postnatal ontogenesis of rats the sensitivity of RyR, including RyR2, to dantrolene is higher than in adult animals. Changes in RyR activity level do not prevent the development of pathological forms of heart rhythm that developing in rats after the physostigmine injection.
- Subjects :
- 0301 basic medicine
Chronotropic
medicine.medical_specialty
Physostigmine
Respiratory rate
Ryanodine receptor
Chemistry
General Medicine
030204 cardiovascular system & hematology
musculoskeletal system
Dantrolene
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Endocrinology
Internal medicine
Heart rate
cardiovascular system
medicine
Cholinergic
Respiratory system
medicine.drug
Subjects
Details
- ISSN :
- 25421875 and 16834100
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Reviews on Clinical Pharmacology and Drug Therapy
- Accession number :
- edsair.doi...........a9d7efe978f08cba31c82fafb44b17e4