Back to Search
Start Over
NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus
- Source :
- Clinical and Experimental Pharmacology and Physiology. 38:550-554
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- 1. In the present study, we investigated the associations of nicotinamide phosphoribosyltransferase (NAMPT)-3186 C/T and -948G/T polymorphisms with the risk of Type 2 diabetes mellitus (T2DM) and their impact on the efficacy of repaglinide in Chinese Han T2DM patients. 2. In all, 170 patients with T2DM and 129 healthy controls were genotyped for NAMPT-948G>T and -3186C>T polymorphisms. Thirty-five patients with different NAMPT -3186 C/T genotypes and the same organic anion-transporting polypeptide 1B1 (OATP1B1521) T/C genotype were randomly selected to undergo 8 weeks preprandial repaglinide treatment (1 mg, three times daily). Serum fasting plasma glucose (FPG), post-prandial plasma glucose (PPG), glycated haemoglobin (HbAlc), fasting serum insulin (FINS), post-prandial serum insulin (PINS), triglyceride (TG), total cholesterol (CHO), homeostasis model assessment of insulin resistance (HOMA-IR), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were determined before and after repaglinide treatment. 3. After repaglinide treatment for 8 consecutive weeks, there were significantly decreases in PFG, PPG, HbAlc, CHO and LDL-C, and increases in FINS, HDL-C and the HDL-C : LDL-C ratio, in T2DM patients. The elevated PINS value in patients with CT genotypes was significantly lower than that in patients with the CC and TT genotypes (P T polymorphism is significantly associated with plasma levels of PINS and CHO in Chinese T2DM patients with repaglinide monotherapy.
- Subjects :
- Pharmacology
medicine.medical_specialty
endocrine system diseases
Triglyceride
Physiology
business.industry
Nicotinamide phosphoribosyltransferase
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
Type 2 diabetes
medicine.disease
Repaglinide
chemistry.chemical_compound
Endocrinology
Insulin resistance
chemistry
Physiology (medical)
Internal medicine
Diabetes mellitus
Genotype
medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 03051870
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Pharmacology and Physiology
- Accession number :
- edsair.doi...........a97fd265a2608c418025cd77dafdb3d1