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Cognitive profile of LRRK2 -related Parkinson's disease

Authors :
Kathryn A. Chung
Jennifer G. Goldman
Catherine O. Johnson
Joseph F. Quinn
Alberto J. Espay
Karen L. Edwards
Brenna Cholerton
Vivianna M. Van Deerlin
Stewart A. Factor
Johnna Devoto
Amie Peterson
Fredy J. Revilla
Thomas J. Montine
Daniel Weintraub
Marilyn S. Albert
Cathy Wood-Siverio
Rebecca Rausch
Shu Ching Hu
Ignacio F. Mata
Glenn T. Stebbins
John Q. Trojanowski
Zbigniew K. Wszolek
James B. Leverenz
Sindhu Srivatsal
Beate Ritz
Jing Zhang
Kathleen S. Montine
Liana S. Rosenthal
Ted M. Dawson
Bryan Bernard
Ryan J. Uitti
Cyrus P. Zabetian
Dennis W. Dickson
Source :
Movement Disorders. 30:728-733
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

Author(s): Srivatsal, S; Cholerton, B; Leverenz, JB; Wszolek, ZK; Uitti, RJ; Dickson, DW; Weintraub, D; Trojanowski, JQ; Van Deerlin, VM; Quinn, JF; Chung, KA; Peterson, AL; Factor, SA; Wood-Siverio, C; Goldman, JG; Stebbins, GT; Bernard, B; Ritz, B; Rausch, R; Espay, AJ; Revilla, FJ; Devoto, J; Rosenthal, LS; Dawson, TM; Albert, MS; Mata, IF; Hu, SC; Montine, KS; Johnson, C; Montine, TJ; Edwards, KL; Zhang, J; Zabetian, CP | Abstract: Background: Increasing evidence suggests that genetic factors play a role in the variability associated with cognitive performance in Parkinson's disease (PD). Mutations in the LRRK2 gene are the most common cause of monogenic PD; however, the cognitive profile of LRRK2-related PD is not well-characterized. Methods: A cohort of 1,447 PD patients enrolled in the PD Cognitive Genetics Consortium was screened for LRRK2 mutations and completed detailed cognitive testing. Associations between mutation carrier status and cognitive test scores were assessed using linear regression models. Results: LRRK2 mutation carriers (n=29) demonstrated better performance on the Mini Mental State Examination (P=0.03) and the Letter-Number Sequencing Test (P=0.005). A smaller proportion of LRRK2 carriers were demented (P=0.03). Conclusions: Our cross-sectional study demonstrates better performance on certain cognitive tests, as well as lower rates of dementia in LRRK2-related PD. Future longitudinal studies are needed to determine whether LRRK2 mutation carriers exhibit slower cognitive decline.

Details

ISSN :
08853185
Volume :
30
Database :
OpenAIRE
Journal :
Movement Disorders
Accession number :
edsair.doi...........a936a6eaacaf0e3dc753a521b599ae13
Full Text :
https://doi.org/10.1002/mds.26161