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Regulation of intestinal morphology and GALT by pituitary hormones in the rat
- Source :
- Annals of the New York Academy of Sciences. 1261:72-78
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Here, the effects of neurointermediate (NIL), anterior (AL), and total hypophysectomy (HYPOX) on ileal mucosa cells and gut-associated lymphoid tissue (GALT) are reported. Compared with the sham-operated (SHAM) rats, the villi height and goblet cells numbers were significantly decreased in all groups. Lamina propria area decreased in AL and HYPOX, but not in NIL animals. CD8(+) but not CD4(+) lymphocytes decreased in the HYPOX and NIL groups. Paneth cells did not change, while IgA cells, IgM cells, and secretory IgA were significantly decreased in all groups. NIL but not AL animals lost significant numbers of IgA cells and secretory IgA. In summary, pituitary hormones exert lobe-specific regulatory effects on the gut and on GALT.
- Subjects :
- Lamina propria
medicine.medical_specialty
Hypophysectomy
General Neuroscience
Gut-associated lymphoid tissue
medicine.medical_treatment
Intestinal morphology
Biology
digestive system
General Biochemistry, Genetics and Molecular Biology
medicine.anatomical_structure
Lymphatic system
Endocrinology
History and Philosophy of Science
Internal medicine
Pituitary hormones
medicine
Total hypophysectomy
CD8
Subjects
Details
- ISSN :
- 00778923
- Volume :
- 1261
- Database :
- OpenAIRE
- Journal :
- Annals of the New York Academy of Sciences
- Accession number :
- edsair.doi...........a88c685ee12071de7535f84adbb94a3b