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THE CONTRASTING PROPERTIES OF A NEW OIL IODINATED PREPARATION LINOYODOL IN VITRO AND IN VIVO
- Source :
- Russian Journal of Oncology. 22:277-280
- Publication Year :
- 2017
- Publisher :
- ECO-Vector LLC, 2017.
-
Abstract
- The research is devoted to the study of the contrasting properties of new iodinated oil drug Linoyodol (100% solution) by in vitro (monitoring: well-known contracter Omnipak and saline) and in vivo under intraarterial injection of 0.1-1.0 ml to a. femoralis of rats with a intramuscular tumor (n = 18) with the aid of X-ray and СT. In vitro contrasting was shown to be less intensive, than in Omnipak, and in vivo is manifested in a lethal dose of 1.0 ml of highly viscid solution. The conclusion was drawn concerning low contrasting of Linoyodol in vitro with the limitation of its administration of the viscid solution to rats into artery of rather small size. The last demands the use of larger laboratory animals with an artery of sufficient size and decrease of the viscosity of the injection solution.
- Subjects :
- Biochemistry
In vivo
Chemistry
General Medicine
In vitro
Subjects
Details
- ISSN :
- 24129119 and 10289984
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Russian Journal of Oncology
- Accession number :
- edsair.doi...........a8809c033a436ffaeadfb60cbcb97683