OP31.08: Intima media thickness and lipid profile at delivery in pregnancies complicated by intrauterine growth restriction

centile with normal Doppler umbilical artery (UA) and intrauterine growth restriction (IUGR), EFW 2 standard deviation. aIMT was measured by ultrasonography during third trimester. Carbohydrate profile in mothers and fetuses at delivery was assessed. Results: Between 165 women enrolled, 97 were controls, 57 SGA and 11 IUGR. There were no significant differences in maternal age and BMI among the groups. IUGR presented a lower birth weight and a higher aIMT compared to SGA and AGA fetuses (P < 0.05). There was a significant positive correlation between maternal and fetal values for adiponectin, insulin, glucose and HOMA index. Adiponectin was significantly lower in the mother than in the fetus (P < 0.05) while NEFA and glucose were higher (P < 0.05). Maternal adiponectin and NEFA in SGA were significantly higher than in AGA (P < 0.05); moreover there was a significant positive correlation of fetal glucose with fetal aIMT not observed in AGA (P < 0.05), and in SGA fetuses a high aIMT correlated with high insulin resistance. In addition, in IUGR high aIMT was associated with high insulin concentrations. A significant negative correlation between maternal adiponectin and fetal aIMT was found in AGA, while in the SGA group the correlation was significantly positive (P < 0.05). Conclusions: This study suggests that aIMT could be associated with fetal glucose metabolism alteration, and that maternal metabolic disorders might reflect on fetal metabolism and influence the structure of fetal vessels.