Back to Search
Start Over
Increased post-operative complications with methylene blue versus lymphazurin in sentinel lymph node biopsies for skin cancers
- Source :
- Journal of Surgical Oncology. 103:421-425
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Background Sentinel lymph node biopsy (SNLB) is the standard of care in staging of melanoma and other skin cancers. Early studies used lymphazurin (LZ) for SLNB. A national shortage of LZ promoted methylene blue (MB) as an alternate stain. Objective This study compares complication rates between LZ and MB in SLNB patients, and the reliability dyes in locating sentinel lymph nodes. Methods Charts were reviewed for patients who underwent SLNB for skin cancers between September 2006 and November 2008 at Penn State Hershey Medical Center. The type and quantity of dye, the presence of blue stained sentinel nodes, and any complications were recorded. Results Ninety-three patients underwent SLNB (46 LZ, 47 MB). The amount of dye used was similar (avg. 0.93 ml LZ, 1.24 ml MB). The complication rate of LZ was 8.7%, and MB was 25.5%. There was significantly more (P = 0.003) skin graft complications in the MB patients (6/12) versus LZ (0/15). Conclusions There is a higher rate of complications with MB, especially with skin grafting. The reported risk of anaphylaxis with LZ has not been reported in volumes
- Subjects :
- medicine.medical_specialty
medicine.diagnostic_test
business.industry
Melanoma
medicine.medical_treatment
Sentinel lymph node
General Medicine
medicine.disease
Stain
Surgery
chemistry.chemical_compound
Oncology
chemistry
Biopsy
Medicine
Skin grafting
Radiology
Lymph
Complication
business
Methylene blue
Subjects
Details
- ISSN :
- 00224790
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Oncology
- Accession number :
- edsair.doi...........a7feb7b8733453f0211fcfb8ecb517c8