Approach to the aphthous lesions of the oral mucosa

Aphthous oral cavity lesions are common in clinical practice that negatively affect the quality of life. It is possible to reveal the etiological cause in aphthous lesions, with detailed history, physical examination findings, and appropriate laboratory evaluation. In this article, we aimed to review the differential diagnosis by examining the conditions that need to be questioned with clinical clues to reveal the correct etiological cause in a patient presenting with the complaint of oral aphthae.