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Aflatoxin B1exposure increases the risk of cirrhosis and hepatocellular carcinoma in chronic hepatitis B virus carriers
- Source :
- International Journal of Cancer. 141:711-720
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- The relation between aflatoxin B1 (AFB1 ) and cirrhosis in chronic carriers of hepatitis B virus (HBV) remains inconclusive. This case-control study nested in a large community-based cohort aimed to assess the effect of AFB1 exposure on cirrhosis and HCC in chronic HBV carriers. Serum AFB1 -albumin adduct levels at study entry were measured in 232 cirrhosis cases, 262 HCC cases and 577 controls. Multivariate-adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were estimated using logistic regression. Among all chronic HBV carriers, the time intervals between study entry and diagnosis of HCC, cirrhosis, cirrhotic HCC, and non-cirrhotic HCC were all significantly (p
- Subjects :
- 0301 basic medicine
Hepatitis B virus
Cancer Research
medicine.medical_specialty
Cirrhosis
business.industry
Case-control study
Hepatitis B
medicine.disease
medicine.disease_cause
Gastroenterology
digestive system diseases
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Blood serum
Oncology
030220 oncology & carcinogenesis
Internal medicine
Hepatocellular carcinoma
medicine
Liver cancer
Viral hepatitis
business
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 141
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi...........a7a086780d47f79e64e3f043a50bc4d4