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Multiarmed Bandit Designs for Phase I Dose-Finding Clinical Trials With Multiple Toxicity Types

Authors :
Guodong Pang
Lan Jin
Demissie Alemayehu
Source :
Statistics in Biopharmaceutical Research. 15:164-177
Publication Year :
2021
Publisher :
Informa UK Limited, 2021.

Abstract

The goal of a phase I dose-finding trial is to determine the dose level of a new drug with acceptable toxicity. The optimal dose level is determined by sequentially allocating patients to increasin...

Details

ISSN :
19466315
Volume :
15
Database :
OpenAIRE
Journal :
Statistics in Biopharmaceutical Research
Accession number :
edsair.doi...........a78a28eb874b61cfd006edd74b09ed09