256 Mechanism-based Preclinical PK/PD/E Relationships for Alisertib, an Investigational Small-molecule Inhibitor of Aurora A Kinase, in a Range of Human Solid Tumor Xenografts

Authors :: S. Palani
S. Balani
Manish R. Patel
J. Ecsedy
Arijit Chakravarty
M. Manfredi
W.C. Shyu
Mengkun Zhang
J. Mettetal
Karthik Venkatakrishnan
Source :: European Journal of Cancer. 48:78-79
Publication Year :: 2012
Publisher :: Elsevier BV, 2012.

Subjects :: Cancer Research
chemistry.chemical_compound
Range (particle radiation)
Oncology
chemistry
Alisertib
Aurora A kinase
Mechanism based
Pharmacology
Solid tumor
Small molecule
PK/PD models

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