An enantiodivergent synthesis of threo β-amino alcohols: Preparation of key intermediates for bestatin and the related peptides

An enantiodivergent method for preparation of threo β-amino alcohols and threo 1,2-diamines has been developed starting with a chiral aziridine 1. Unusual amino acid derivatives 3 and 5, which are key synthetic intermediates for bestatin and the related peptides, have been prepared.