Alanine aminotransferase as marker of cardiometabolic risk in overweight adolescents

Background: Alanine aminotransferase is a marker present in cases of liver damage, such as non-alcoholic fatty liver disease. Objective: To identify the relationship between serum alanine aminotransferase values and cardiovascular risk markers in overweight adolescents. Methods: In this cross-sectional study, were recruited 120 overweight adolescents aged 10-19 years. Height, weight and waist circumference were evaluated and used to calculate the body mass index. Taper index and arterial pressure were measured. Biomarkers lipid and glycemic profiles, triglycerides, high-density lipoprotein, alanine aminotransferase and aspartate aminotransferase values were measured and the triglyceride/high-density lipoprotein ratio was calculated. Statistical analysis was performed using Pearson's correlation coefficient and Fisher's exact test. Results: Boys showed significantly increased values of alanine aminotransferase (p Conclusion: Important correlations were identified between serum alanine aminotransferase values and cardiovascular risk markers in overweight adolescents.