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Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels
- Source :
- British Journal of Pharmacology. 172:3495-3509
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Background and PurposeTransient receptor potential canonical (TRPC) channels play important roles in a broad array of physiological functions and are involved in various diseases. However, due to a lack of potent subtype-specific inhibitors the exact roles of TRPC channels in physiological and pathophysiological conditions have not been elucidated.
Details
- ISSN :
- 00071188
- Volume :
- 172
- Database :
- OpenAIRE
- Journal :
- British Journal of Pharmacology
- Accession number :
- edsair.doi...........a65bc7c7026021be46ed8cee1aa05ea8
- Full Text :
- https://doi.org/10.1111/bph.13140