Back to Search Start Over

Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

Authors :
Meng Wu
Xuechuan Hong
Xianming Hu
Melissa R. Miller
Yungang Lu
Michael X. Zhu
Zixin Deng
Owen B. McManus
Chunrong Qu
Huai-Rong Luo
Dhananjay P. Thakur
Yingmin Zhu
Min Li
Jinmei Zhu
Jinbin Tian
Source :
British Journal of Pharmacology. 172:3495-3509
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

Background and PurposeTransient receptor potential canonical (TRPC) channels play important roles in a broad array of physiological functions and are involved in various diseases. However, due to a lack of potent subtype-specific inhibitors the exact roles of TRPC channels in physiological and pathophysiological conditions have not been elucidated.

Details

ISSN :
00071188
Volume :
172
Database :
OpenAIRE
Journal :
British Journal of Pharmacology
Accession number :
edsair.doi...........a65bc7c7026021be46ed8cee1aa05ea8
Full Text :
https://doi.org/10.1111/bph.13140