Back to Search
Start Over
Recognition of iron-free siderophores by TonB-dependent iron transporters
- Source :
- Molecular Microbiology. 54:14-22
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- TonB-dependent iron transporters reside in the outer membranes of Gram-negative bacteria, transporting ferric-complexes into the periplasm by a mechanism requiring proton motive force and an integral inner membrane complex, TonB-ExbB-ExbD. Certain TonB-dependent transporters contain an additional domain at the N-terminus, which interacts with an inner membrane regulatory protein and a cytoplasmic sigma factor to induce transcription of iron transport genes when a ferric-ligand is bound at the extracellular surface of the transporter. Transport of the ferric-ligand is apparently not necessary for transcription induction. Recent biophysical and crystallographic experiments have shown that this subclass of TonB-dependent iron transporters can bind iron-free ligands, whereas only the ferric-ligands are transported into the periplasm. This review focuses on the ligand binding properties of these transporters and includes a discussion of the biological function of the additional domain, the mechanism of transcription induction and the mechanism of ferric-ligand transport.
- Subjects :
- 0303 health sciences
Siderophore
Inner membrane complex
030306 microbiology
Chemiosmosis
Transporter
Periplasmic space
Biology
Microbiology
03 medical and health sciences
Biochemistry
Sigma factor
Transcription (biology)
Biophysics
bacteria
Inner membrane
Molecular Biology
030304 developmental biology
Subjects
Details
- ISSN :
- 13652958 and 0950382X
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Molecular Microbiology
- Accession number :
- edsair.doi...........a5bd3fffdbea206045e0017447dc90e9