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A common TCN1 loss-of-function variant is associated with lower vitamin B12 concentration in African Americans
- Source :
- Blood. 131:2859-2863
- Publication Year :
- 2018
- Publisher :
- American Society of Hematology, 2018.
-
Abstract
- TO THE EDITOR: Vitamin B12 (VB12), or cobalamin, is a water-soluble vitamin. It serves as an enzyme cofactor in the 1-carbon metabolism pathway, which plays a key role in a wide range of biological processes, including red blood cell (RBC) formation, DNA synthesis, and myelination of the central
- Subjects :
- 0301 basic medicine
Vitamin
medicine.medical_specialty
biology
DNA synthesis
Immunology
Genome-wide association study
Cell Biology
Hematology
030105 genetics & heredity
Biochemistry
Cobalamin
Cofactor
03 medical and health sciences
chemistry.chemical_compound
Red blood cell
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
Internal medicine
medicine
biology.protein
Vitamin B12
Loss function
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi...........a57b6509a0d821889d44102295010af7
- Full Text :
- https://doi.org/10.1182/blood-2018-03-841023