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Mechanism of Pi-induced Vascular Calcification - Regulation of Growth Arrest-Specific Gene 6 (Gas6)-Mediated Survival Pathway
- Source :
- Journal of Atherosclerosis and Thrombosis. 15:63-68
- Publication Year :
- 2008
- Publisher :
- Japan Atherosclerosis Society, 2008.
-
Abstract
- Vascular calcification is clinically important in the development of cardiovascular disease. It has been suggested that apoptosis is one of the processes regulating calcification in vascular smooth muscle cells (VSMC). In this review, we discuss the role of apoptosis in inorganic phosphate (Pi)- induced calcification, focusing on regulation of the survival pathway mediated by growth arrest- specific gene 6 (Gas6). Further, we mention the beneficial effect of statins mediated by inhibition of apoptosis which is accompanied by restoration of the Gas6-mediated survival pathway. These findings indicate that Gas6 is a novel target of statins' effects to prevent vascular calcification.
- Subjects :
- medicine.medical_specialty
Vascular smooth muscle
Mechanism (biology)
GAS6
Biochemistry (medical)
Biology
medicine.disease
Endocrinology
Downregulation and upregulation
Apoptosis
Internal medicine
Internal Medicine
medicine
Pi
Cancer research
Cardiology and Cardiovascular Medicine
Vascular calcification
Calcification
Subjects
Details
- ISSN :
- 18803873 and 13403478
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Journal of Atherosclerosis and Thrombosis
- Accession number :
- edsair.doi...........a55330926d506f75749809a88d10f7b7