Development and Application of Catalytic Highly Enantioselective Hetero-Diels-Alder Reactions of Aldehydes and Ketones

The hetero-Diels-Alder reaction of carbonyl compounds with conjugated dienes [eq (1)] constitutes one of the cornerstone reactions in organic chemistry.1 The products formed in this reaction are of fundamental importance in chemistry, and numerous examples of the use of these compounds in academia and industry have appeared.