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Synthesis and Antifungal Activity Evaluation of 1-(2-Benzyloxy-2-Phenylethyl)-1,2,3-Triazole Miconazole Analogs
- Source :
- Pharmaceutical Chemistry Journal. 55:436-440
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Aseries of 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivatives (Miconazole analogs) was obtained via copper catalyzed azide-alkyne cycloaddition as the key step. The synthesized compounds were evaluated for antimicrobial activity against Candida genus strains as well as filamentous fungi (Mucor hiemalis, Aspergillus fumigatus and Rhizopus oryzae). A 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivative exhibited remarkable selectivity comparable to that of Itraconazole against Rhizopus oryzae.
Details
- ISSN :
- 15739031 and 0091150X
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Chemistry Journal
- Accession number :
- edsair.doi...........a500ac5a83da4aff79b1371fc7144437
- Full Text :
- https://doi.org/10.1007/s11094-021-02440-x