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Synthesis and Antifungal Activity Evaluation of 1-(2-Benzyloxy-2-Phenylethyl)-1,2,3-Triazole Miconazole Analogs

Authors :
Juana Suárez-García
Ma-Angeles Cano-Herrera
Alejandra Ramírez-Villalva
M. V. Basavanag Unnamatla
Aydeé Fuentes-Benítes
Erick Cuevas-Yañez
Marco A. García-Eleno
Nieves Zavala-Segovia
Source :
Pharmaceutical Chemistry Journal. 55:436-440
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

Aseries of 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivatives (Miconazole analogs) was obtained via copper catalyzed azide-alkyne cycloaddition as the key step. The synthesized compounds were evaluated for antimicrobial activity against Candida genus strains as well as filamentous fungi (Mucor hiemalis, Aspergillus fumigatus and Rhizopus oryzae). A 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivative exhibited remarkable selectivity comparable to that of Itraconazole against Rhizopus oryzae.

Details

ISSN :
15739031 and 0091150X
Volume :
55
Database :
OpenAIRE
Journal :
Pharmaceutical Chemistry Journal
Accession number :
edsair.doi...........a500ac5a83da4aff79b1371fc7144437
Full Text :
https://doi.org/10.1007/s11094-021-02440-x