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Supervised Dimensionality Reduction of Single-cell Features from Label-free Multimodal Images for T Cell Subtype Classification

Authors :
Elizabeth Lee
Maciej Baranski
Marvin Chew
Wei-Xiang Sin
Ka-Wai Cheung
Lisa Tucker-Kellogg
Derrick Yong
Michael Birnbaum
George Barbastathis
Source :
Frontiers in Optics + Laser Science 2021.
Publication Year :
2021
Publisher :
Optica Publishing Group, 2021.

Abstract

Nonlinear dimensionality reduction of features extracted from single T cell images show localization of partial cells, CD4+ and CD8+ T cells in the lower-dimensional space, showing potential T cell subtype classification from label-free imaging.

Details

Database :
OpenAIRE
Journal :
Frontiers in Optics + Laser Science 2021
Accession number :
edsair.doi...........a4da8802a8a7e2e004d56c3f9c4d69bc
Full Text :
https://doi.org/10.1364/fio.2021.fm3d.3