Combined Topo-Guided laser Vision Correction (LASIK) with Concurrent Prophylactic High-Fluence Corneal Collagen Crosslinking (CXL) in Myopic Patients with Normal Cornea

Background: Corneal ectasia is a serious vision-threatening complication of laser-assisted in-situ keratomileusis (LASIK). Objective: The aim of the work was to evaluate the efficacy and safety of ultraviolet A (UVA) irradiation crosslinking in concurrent with LASIK in myopic patient with normal cornea to avoid post LASIK ectasia. Patients and Methods: This Prospective randomized interventional study included 60 eyes of 30 consecutive patient who were scheduled for LASIK surgery, all of them were myopic with normal cornea with no pervious refractive surgery. They were candidate for Combined Topo-Guided LASIK with accelerated CXL. This was done in a private eye hospital between Jun 2018 and Jun 2019. Results: The preoperative uncorrected visual acuity (UCVA) ranged from 0.05- 0.1 with mean 0.075±0.02 and preoperative best corrected visual acuity (BCVA) ranged 0.2- 1.0 with mean 0.58±0.13 and post-operative UCVA at 6 months showed ranged 0.2-1.0 with mean 0.55±0.16, and postoperative UCVA at 1 year showed ranged 0.2-1.0 with mean 0.56±0.13,. The improvement in visual acuity from 0.075±0.02 UCVA preoperatively show statistically significant difference (P > 0.05) because we compared the results with the preoperative BCVA 0.58±0.13 postoperatively at 6 months. However, t-Paired Sample t-test; p-value < 0.05 S. Conclusion: It could be concluded that LASIK combined with a prophylactic CXL intervention appears to provide predictability as well as refractive and keratometric stability. The data reported in this study provide evidence of the safety and efficacy of this approach.