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The Role of the Oxytocin System in Anxiety Disorders
- Source :
- Advances in Experimental Medicine and Biology ISBN: 9789813297043
- Publication Year :
- 2020
- Publisher :
- Springer Singapore, 2020.
-
Abstract
- Oxytocin, a neuropeptide synthesized by the hypothalamus, plays a central role in human social behavior, social cognition, anxiety, mood, stress modulation, and fear learning and extinction. The relationships between oxytocin and psychiatric disorders including depression, anxiety, schizophrenia, and autism spectrum disorder have been extensively studied. In this chapter, we focus on the current knowledge about oxytocin and anxiety disorder. We discuss the anxiolytic effects of oxytocin in preclinical and clinical findings, possible related neurobehavioral mechanisms (social cognition, fear learning, and extinction), related neurotransmitter and neuroendocrine systems (hypothalamus-pituitary-adrenal axis, serotoninergic, and GABAergic systems), and studies regarding plasma levels of oxytocin, genetic and epigenetic findings, and effects of intranasal oxytocin in DSM-5 anxiety disorder (primarily social anxiety disorder and separation anxiety disorder) patients.
- Subjects :
- endocrine system
medicine.drug_class
Panic disorder
Social anxiety
Separation anxiety disorder
medicine.disease
Anxiolytic
Specific phobia
03 medical and health sciences
0302 clinical medicine
Schizophrenia
medicine
Anxiety
030212 general & internal medicine
medicine.symptom
Psychology
hormones, hormone substitutes, and hormone antagonists
Anxiety disorder
Clinical psychology
Subjects
Details
- ISBN :
- 978-981-329-704-3
- ISBNs :
- 9789813297043
- Database :
- OpenAIRE
- Journal :
- Advances in Experimental Medicine and Biology ISBN: 9789813297043
- Accession number :
- edsair.doi...........a478cd8bc1f1c657434c253aad88918a