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Cardiac MR With Late Gadolinium Enhancement in Acute Myocarditis With Preserved Systolic Function
- Source :
- Journal of the American College of Cardiology. 70:1977-1987
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background The prognostic role of cardiac magnetic resonance (CMR) and late gadolinium enhancement (LGE) has not been clarified in acute myocarditis (AM) with preserved left ventricular (LV) ejection fraction (EF). Objectives This study sought to evaluate the role of CMR and LGE in the prognosis of AM with preserved LVEF. Methods This study analyzed data from ITAMY (ITalian multicenter study on Acute MYocarditis) and evaluated CMR results from 386 patients (299 male; mean age 35 ± 15 years) with AM and preserved LVEF. Clinical follow-up was performed for a median of 1,572 days. A clinical combined endpoint of cardiac death, appropriate implantable cardioverter-defibrillator firing, resuscitated cardiac arrest, and hospitalization for heart failure was used. Results Among the 374 patients with suitable images, LGE involved the subepicardial layer inferior and lateral wall in 154 patients (41%; IL group), the midwall layer of the anteroseptal wall in 135 patients (36%; AS [anteroseptal] group), and other segments in 59 patients (16%; other-LGE group), and it was absent in 26 patients (no-LGE group). The AS group had a greater extent of LGE and a higher LV end-diastolic volume index than other groups, but levels of inflammatory markers were lower than in the other groups. Kaplan-Meier curve analysis indicated that the AS group had a worse prognosis than the other groups (p Conclusions In patients with AM and preserved LVEF, LGE in the midwall layer of the AS myocardial segment is associated with a worse prognosis than other patterns of presentation.
- Subjects :
- medicine.medical_specialty
Ejection fraction
business.industry
Curve analysis
Systolic function
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Acute myocarditis
Multicenter study
Internal medicine
cardiovascular system
medicine
Cardiology
Late gadolinium enhancement
In patient
cardiovascular diseases
Cardiology and Cardiovascular Medicine
Cardiac magnetic resonance
business
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi...........a39640fad946aa52bdc870aea6906321