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Randomised clinical trial: individualised vs. weight-based dosing of azathioprine in Crohn's disease
- Publication Year :
- 2014
- Publisher :
- The University of North Carolina at Chapel Hill University Libraries, 2014.
-
Abstract
- Azathioprine (AZA), a pro-drug metabolized to the active metabolites 6-thioguanine nucleotides (6TGN), is a steroid-sparing therapy for Crohn’s disease (CD). This trial investigated whether AZA therapy is optimized by individualized dosing based on thiopurine methyltransferase (TPMT) activity and 6TGN concentrations.
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........a3721623ba5e9b9be131647e1aba8e48
- Full Text :
- https://doi.org/10.17615/7jxn-w918