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In vitro degradation and biocompatibility of Mg-Li-Ca alloys—the influence of Li content
- Source :
- Science China Materials. 61:607-618
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Mg-Li based alloys hold much attention as potential biomedical materials due to their excellent ductility. A reduced mechanical strength and concern for biocompatibility are exhibited for Mg-Li binary alloys due to the presence of Li element. Addition of the Ca element into Mg-Li alloys leads to an improvement in mechanical strength and biocompatibility. In the present work, the microstructure, mechanical property and corrosion behaviors of three kinds ( α , α + β , β ) of as-extruded Mg-Li (1, 9 and 15 wt.%)-1Ca alloys were investigated using optical microscope, X-ray diffraction (XRD), tensile, immersion and electrochemical polarization measurements. In vitro biocompatibility was evaluated by cytotoxicity assays, hemolysis and four coagluation tests. The results indicated that the Mg-1Li-1Ca and Mg-15Li-1Ca alloys were characterized by α -Mg and β -Li phases besides Mg2Ca particles, respectively; while the Mg-9Li-1Ca by dual ( α -Mg+ β -Li) phase together with Mg2Ca phase. The Mg-1Li-1Ca alloy had the highest ultimate tensile strength (UTS) and yield strength (YS) and the lowest elongation (EL) to failure (10.1±1.24%) as well. The EL for the Mg-9Li-1Ca alloy was the highest (52.2±0.01%). The long-term immersion tests revealed a decrease in corrosion resistance with increasing Li content. The results of cytotoxicity assays clearly showed that the Mg-Li-Ca alloys demonstrated no toxicity to L-929 cells in 10% concentration of extracts. The Mg-1Li-1Ca alloy also exhibited an acceptable hemolysis ratio. The results of four coagulation tests designated no sign of thrombogenicity for the Mg-Li-Ca alloys except for the Mg-15Li-1Ca alloy.
- Subjects :
- Materials science
Biocompatibility
Alloy
Metallurgy
Biomaterial
02 engineering and technology
engineering.material
010402 general chemistry
021001 nanoscience & nanotechnology
Microstructure
01 natural sciences
0104 chemical sciences
Corrosion
Ultimate tensile strength
engineering
General Materials Science
Magnesium alloy
0210 nano-technology
Ductility
Nuclear chemistry
Subjects
Details
- ISSN :
- 21994501 and 20958226
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Science China Materials
- Accession number :
- edsair.doi...........a31df04943643488cae917820d74631e