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Stereoselective alkylations of a bicyclic lactam derived from pyroglutamic acid

Authors :
Jose S. Madalengoitia
Rui Zhang
Floyd Brownewell
Source :
Tetrahedron Letters. 40:2707-2710
Publication Year :
1999
Publisher :
Elsevier BV, 1999.

Abstract

Improvements in the stereoselective alkylation of a bicyclic lactam derived from pyroglutamic acid are described. This methodology is used to synthesize a conformationally constrained homo-glutamic acid analog.

Subjects

Subjects :
chemistry.chemical_compound
Bicyclic molecule
Chemistry
Organic Chemistry
Drug Discovery
Lactam
Organic chemistry
Stereoselectivity
Pyroglutamic acid
Alkylation
Biochemistry

Details

ISSN :
00404039
Volume :
40
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........a3036f8958eda8e004d23822d700dbff
Full Text :
https://doi.org/10.1016/s0040-4039(99)00345-7
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