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Synthesis of 2-aminoquinazolines fromortho-fluorobenzaldehydes
- Source :
- Journal of Heterocyclic Chemistry. 34:385-387
- Publication Year :
- 1997
- Publisher :
- Wiley, 1997.
-
Abstract
- The reaction of guanidine carbonate with various ortho-fluorobenzaldehydes in N,N-diinethylacetamide was investigated as a potential route for preparing 2-aminoquinazolines. Eleven new 2-aminoquinazolines were elaborated in this manner in low to moderate yields. In general the best results were obtained with ortho-fluorobenzaldehydes possessing an electron withdrawing substituent at the other ortho position. Complex mixtures were obtained using 2-fluorobenzaldehyde, 2,5-difluorobenzaldehyde and 2-fluoro-5-methoxybenzaldehyde which were not resolved.
Details
- ISSN :
- 19435193 and 0022152X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of Heterocyclic Chemistry
- Accession number :
- edsair.doi...........a2a10419868207658bfb8e3ceac3c10c