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Synthesis of bioactive fluoropyrrolidines via copper(<scp>i</scp>)-catalysed asymmetric 1,3-dipolar cycloaddition of azomethine ylides
- Source :
- Chemical Science. 13:1398-1407
- Publication Year :
- 2022
- Publisher :
- Royal Society of Chemistry (RSC), 2022.
-
Abstract
- Chiral fluoropyrrolidines were synthesized by Cu(i)-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides with less active fluorinated styrenes, with broad substrate scope and high yield, stereoselectivity and biological activity.
- Subjects :
- General Chemistry
Subjects
Details
- ISSN :
- 20416539 and 20416520
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Chemical Science
- Accession number :
- edsair.doi...........a2938d4b8b9953d2695a474e490a1bd2