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Synthesis and characterization of chitosan/cloisite 30B film for controlled release of ofloxacin
- Source :
- Journal of Applied Polymer Science. 123:2588-2594
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- In this research program, chitosan film was prepared by blending chitosan with Cloisite 30 B at different concentrations 0 wt %, 1 wt %, and 2.5 wt %. The blends were characterized by Fourier transmission infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis. From the FTIR spectra the various groups present in chitosan/C 30 B blend were monitored. The homogeneity, morphology, and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The most suitable form of blend was taken and used as a carrier for the controlled release of ofloxacin. The swelling studies have been carried out at different drug loading. Drug release kinetics was analyzed by plotting the cumulative release data versus time by fitting to an exponential equation which indicated the occurrence of non-Fickian type of kinetics. The drug release was investigated at different pH medium and it was found that the drug release depends upon the pH medium as well as the nature of matrix. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
- Subjects :
- Materials science
Polymers and Plastics
Scanning electron microscope
Kinetics
technology, industry, and agriculture
Infrared spectroscopy
General Chemistry
Controlled release
Surfaces, Coatings and Films
Chitosan
chemistry.chemical_compound
Crystallinity
chemistry
Polymer chemistry
Materials Chemistry
medicine
Fourier transform infrared spectroscopy
Swelling
medicine.symptom
Nuclear chemistry
Subjects
Details
- ISSN :
- 00218995
- Volume :
- 123
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Polymer Science
- Accession number :
- edsair.doi...........a267c7d34f7d9812f7e635775f9a2fe2