Development and Evaluation of Enteric Coated Tablet Containing Diclofenac Sodium

The influence of various polymers on the release rate of Diclofenac Sodium from enteric coated tablets was investigated in an attempt to formulate a delayed release solid dosage forms. Prepared the conventional diclofenac sodium tablets by wet granulation method (non-aqueous) using granulating fluid (isopropyl alcohol). Developed the aqueous coating formula using shacryl and non-aqueous coating formula using HPMCP and optimized the best aqueous coating formula. Coating was performed in a mini coating pan at 107 rpm using low-pressure air atomized liquid spray techniques. Comparative dissolution, disintegration and antiulcer studies were performed on the best products and marketed products. The Comparative antiulcer studies were performed on wister albino rats using conventional, dummy and enteric-coated tablets.