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New dibenzocyclooctadiene lignan from stems of Kadsura heteroclita
- Source :
- Natural Product Research. 36:8-17
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Kadsura heteroclita Roxb. Craib. (Schisandraceae), is a vine plant mainly distributed in southwest part of China. A new dibenzocyclooctadiene lignan, kadsulignan W (1), along with eleven known lignans (2-12) were isolated from chloroform soluble fraction of stems of Kadsura heteroclita. The structure of new lignan was elucidated by extensive spectroscopic techniques, namely one- and two-dimensional NMR spectroscopy, and HRESI-MS analysis. The absolute configuration of the biphenyl ring in the new dibenzocyclooctadiene lignan was discerned by circular dichroism (CD) spectroscopy. Antioxidative effects of these compounds were evaluated on human isolated neutrophils, and compounds 5, 8, 9, and 10 were found to be strongly active with the IC50 of 36.68, 34.41, 35.97, and 33.65 µM, respectively. Furthermore, compound 8 was also found to be cytotoxic against human gastric cancer cells (BGC 823), and human cervical cancer cell lines (HeLa) with the IC50 values of 11.0, and 23.8 µM, respectively.
- Subjects :
- Lignan
Circular dichroism
Chloroform
biology
010405 organic chemistry
Stereochemistry
Organic Chemistry
Absolute configuration
Plant Science
Nuclear magnetic resonance spectroscopy
biology.organism_classification
01 natural sciences
Biochemistry
0104 chemical sciences
Analytical Chemistry
Schisandraceae
HeLa
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
chemistry
Kadsura heteroclita
Subjects
Details
- ISSN :
- 14786427 and 14786419
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Natural Product Research
- Accession number :
- edsair.doi...........a1fa90b2b2c00323f69de032f9eee693