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ChemInform Abstract: Synthesis of 5-Trifluoromethyl-5,8-dideazafolic Acid and 5-Trifluoromethyl-5,8-dideazaisofolic Acid
- Source :
- ChemInform. 22
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- The target folate analogue 5-trifluoromethyl-5,8-dideazafolic acid has been elaborated in a seven-step reaction sequence beginning with 2-fluoro-6-trifluoromethylbenzonitrile. The bridge-reversed isomer 5-trifluoromethyl-5,8-dideazaisofolic acid was prepared in six steps using the common intermediate 2,6-diamino-3,4-dihydro-4-oxo-5-trifluoromethylquinazoline. The key intermediate 2-amino-3,4-dihydro-4-oxo-5-trifluoromethyl-quinazoline was prepared using two distinct synthetic routes and the resulting products were found to be identical.
Details
- ISSN :
- 09317597
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........a189f86bd141f9adf3ea3e81c7f66e21