OP-344 New Generation Anticoagulant Rivaroxaban with Clopidogrel Comparison of the Effects Ischemia Reperfusion Model

Peri-procedural Changes in Serum Arylesterase Acvitivity in Patients Undergoing Elective PCI for Stable CAD. H. Erman, H.A. Cakmak, B. Ikitimur, V. Sozer, Z. Ongen, B. Karadag, R. Gelisgen, G. Simsek, H. Uzun. Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey; Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey; Department of Cardiology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey; Department of Physiology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey; Department of Biochemistry, Yildiz Technical University, Istanbul, Turkey. Introduction: Oxidative stress, characterized by an imbalance between the generation ROS and the capacity of the intrinsic antioxidant defense system, may be implicated in the pathogenesis of cardiovascular diseases. Percutaneous transluminal coronary angioplasty (PTCA) and stent deployment induce production of vascular reactive oxygen species (ROS) and reactive nitrogen species (RNS) leading to post-procedural pathophysiological changes including restenosis, stent thrombosis, and endothelial dysfunction. Previous studies suggest that oxidative stress plays an important role in the pathophysiology of restenosis. Because of the actual mechanism accounting for the increased oxidative stress formation in circulation among patients undergoing PCI is still undefined, we aimed to investigate through the analysis of a novel parameter, namely ARE activity, whether early changes in oxidative stress takes place in stable coronary artery disease (CAD) patients undergoing elective PCI with implantation of stents. Methods: In this study 32 consecutive chronic stable angina patients (mean age 61 9.8 years, 75% male) undergoing PCI for management