Decreased CD5−CD19+CD27+CD43+CD70− B-Cell Subpopulation in Children with Specific Antibody Deficiency

Purpose: Recent studies have reported that CD19+CD20+CD27+CD43+CD70-CD5− B cells produce IgG, IgA, and IgM antibodies to Streptococcus pneumoniae (Spn). In one adult patient with specific antibody deficiency (SAD), the percentage of CD5− CD19+CD20+CD27+CD43+CD70− B cells was decreased. The percentages of CD5−of CD19+CD27+CD43+CD70− B cells in children with SAD were examined in this study. Methods: Clinical and immunologic studies were obtained from a review of medical records. The percentages of CD5− of CD19+CD27+CD43+CD70− B cells were determined by flow cytometry. Results: Patients with SAD had significantly decreased percentages of CD5− of CD19+CD27+CD43+CD70− B cells. There was a significant correlation between decreased percentage of CD5−of CD19+CD27+CD43+CD70− B cells and decreased percentage of protective antibody titers to Spn. Conclusion: Decreased percentage of CD5− of CD19+CD27+CD43+CD70− B cells were identified in patients with SAD and correlated with decreased antibody responses to Spn.