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Immune Tolerance Resulting in a Dramatic Clinical Improvement in a High-Responding Inhibitor Hemophilia A Patient Using Immunosuppression with Mycofenolate Mofetil and a Factor VIII Concentrate Containing Von Willebrand Factor

Authors :
Yacine Taoufik
Anne Rafowicz
Thierry Lambert
Benoît Guillet
Cécile Goujard
Marie Dreyfus
Source :
Blood. 106:3220-3220
Publication Year :
2005
Publisher :
American Society of Hematology, 2005.

Abstract

A 40 year-old Caucasian patient with severe familial hemophilia A (FVIII These preliminary results show that this IT treatment, performed despite a high theoretical risk of failure, resulted in this patient in a dramatic clinical improvement, even though biological criteria of success have not yet been achieved. The respective roles of the type of FVIII concentrate, and of immunosuppression remain to be assessed, as well as the cost/benefit analysis on a longer follow-up period.

Details

ISSN :
15280020 and 00064971
Volume :
106
Database :
OpenAIRE
Journal :
Blood
Accession number :
edsair.doi...........a10f19efe4fb35da660f3ba4455e7396