Efeito mutagênico da água natural (poço, rios Ficha e Minas Gerais, próximos à cidade de Ubiratã, Estado do Paraná, Brasil) em sistema teste animal

Intense industrial development and population growth have been altering the quality of water and innumerous studies have been undertaken to analyze their effects on humans. Due to rivers contamination with agrotoxics, herbicides, pesticides, excess of farming chemical additives and through sewers spilling not properly treated industrial waste, investigating cytotoxic and mutagenic activity of river water becomes all-important. Bone marrow cells of Wistar rats ( Rattus norvegicus ), treated in vivo , through gavage, in subchronic treatment (7 days), were used as experimental animal test system to investigate the effects of well water and water from the rivers Ficha and Minas Gerais, close to the municipality of Ubirata, State of Parana, southern Brazil. Cell division index and metaphase chromosomes were analyzed. The statistical analysis showed that the experiment's water failed to alter cell division cycle of Wistar rats and did not increase number of chromosome aberrations. No cytotoxic and clastogenic effects ensued from this treatment