Changes in nonspecific and immune resistance of the organism in acute dichloroethane intoxication

Experimental acute dichloroethane intoxication (0.75 LD50) weakens the anti-infection resistance, suppresses antibody-dependent cell-mediated cytotoxicity, delayed-type hypersensitivity, and T-dependent humoral immune response and reduces the number of colony-forming units in the spleen. This suppression is probably associated with inhibition of α-naphthyl-AS-acetate esterase in immunocytes.