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A New Monoterpenoid Glucoindole Alkaloid FromDipsacus asper
- Source :
- Natural Product Communications. 15:1934578X2091729
- Publication Year :
- 2020
- Publisher :
- SAGE Publications, 2020.
-
Abstract
- The monoterpenoid glucoindole alkaloids comprise a large class of structurally complex natural products that have attracted widespread attention owing to their biological activities and structural diversity. In the present study, we investigated the constituents of a methanol extract of Dipsacus asper roots and obtained a new monoterpenoid glucoindole alkaloid, (3 R,5 S)-5-carboxyvincosidic acid 22-loganin ester (1), together with the known alkaloid (3 S,5 S)-5-carboxystrictosidic acid 22-loganin ester (dipsaperine) (2). We herein report our structural elucidation of 1 by spectroscopic analysis and its anti-inflammatory activity as revealed by its inhibition of nitric oxide production in lipopolysaccharide-activated RAW264.7 cells.
Details
- ISSN :
- 15559475 and 1934578X
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Natural Product Communications
- Accession number :
- edsair.doi...........a05c21f58d37ddd3061c2a4f13623a5c