ChemInform Abstract: Asymmetric Synthesis of Biologically Active Compounds Bearing a Chiral Sulfinyl Group

The asymmetric synthesis of (R C,SS) and (S C,R S), important intermediates in the synthesis of optically pure Sparsomycin analogs, is discussed. The enantioselective synthesis of both isomers, R and S, of Oxisuran and three of their bioisosters is also described. In both strategies o.p. methanesulfinate esters of DAG were used as starting material.