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Difference in Vitamin D Levels Between Children with Clostridioides difficile Enteritis and Those with Other Acute Infectious Enteritis
- Source :
- Pediatric Gastroenterology, Hepatology & Nutrition. 24:81
- Publication Year :
- 2021
- Publisher :
- The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition, 2021.
-
Abstract
- Purpose A steady increase in Clostridioides difficile enteritis (CDE) has been reported recently. CDE is associated with intestinal dysbiosis, and vitamin D receptors are known to play an important role in this microbial imbalance as immunological regulators. We investigated the difference in vitamin D levels between children with CDE and those with other acute infectious enteritis. Methods This retrospective study was conducted on children below 18 years of age who visited the Gil hospital, underwent investigation to assess vitamin D levels, and had confirmed gastrointestinal infection between January 2015 and December 2018. Patients were divided into two groups: the "CDE group" (n=18) and the "other infectious enteritis group" (n=88); their clinical characteristics, other laboratory results, and vitamin D levels were analyzed. Results There was no difference in gender, age, and seasonal distributions between the CDE and other infectious enteritis groups. Other laboratory results were not significantly different between two groups, excluding serum albumin level (4.52±0.45 g/dL vs. 4.31±0.28 g/dL, p=0.011). The mean 25-hydroxy vitamin D level in the CDE group was higher than that in the control group (18.75±8.11 ng/mL vs. 14.50±6.79 ng/mL, p=0.021). Conclusion Vitamin D levels in the CDE group were lower than normal but higher than the other infectious enteritis group. These results suggested that CDE has a different mechanism or susceptibility associated with vitamin D in children, and even marginal changes in vitamin D levels can act as a risk factor for infection.
- Subjects :
- medicine.medical_specialty
Hepatology
Calcitriol
business.industry
Gastroenterology
Retrospective cohort study
Laboratory results
medicine.disease
Enteritis
Infectious enteritis
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Internal medicine
Pediatrics, Perinatology and Child Health
medicine
Vitamin D and neurology
030211 gastroenterology & hepatology
Risk factor
business
Clostridioides
medicine.drug
Subjects
Details
- ISSN :
- 22348840 and 22348646
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Pediatric Gastroenterology, Hepatology & Nutrition
- Accession number :
- edsair.doi...........9fd0ad9ec486c4c5c3d04a0a5ea1ad61