Abstract P068: The Relationship Of Air Pollution And Menopause On The Progression Of Coronary Artery Calcification In Midlife Women: Study Of Women’s Health Across The Nation

Knowledge of the association between air pollution and atherosclerosis risk has been generated in the general population. Our study targeted middle-aged women during the menopause transition who might be vulnerable to PM2.5 on CAC risk, due to their unique physiological profiles. We assessed the association of PM2.5 and CAC presence/progression in menopause transition women.Women included had data of CAC Agatston score, menopause profile measures, and PM2.5 from the SWAN Heart Ancillary study. The yearly mean baseline PM2.5 was estimated based on monitors within 20km of the women’s home. Logistic regression model was used to estimate the association between PM2.5 and CAC presence (any) and progression (defined), and generalized linear mixed model was used for repeated measures of CAC, adjusting for confounders. Time-varing menopause status and baseline PM2.5 measure time to final menstrual period (FMP), were tested as modifiers by adding interaction terms into the final model.366 women averaging 51.3 years were identified (N=198 pre-/early peri- menopause, N=129 late peri-/natural post- menopause), and 21% women had CAC presence. For the 253 women with two CAC measures, 20.9% had progression. Overall mean PM2.5 was no difference by CAC (p=0.54). There was no association between PM2.5 and CAC presence/progression, in both cross-sectional and longitudinal analyses. The tested interactions were not statistically significant. Although those are non-significant, larger odds ratios with higher precision of PM2.5 to CAC progression were detected among women in late peri-/natural post- menopause (OR=1.08 95% CI 0.74, 1.58) and of 2 years after FMP (OR=1.03 95% CI 0.60, 1.92), as compared to premenopausal women and those within/prior to FMP with lower values of PM2.5. (Table)We observed no evidence that PM2.5 was associated with the CAC presence/progression among middle-aged women overall. The contrasts were sharpened among women after menopause transition. More methodologic work is needed to evaluate the relationships.