Synthesis of 11α-methyl-11β-(arylethynyl) substituted steroids of the estrane series

Authors :: Arwed Cleve
Rudolf Wiechert
Wolfgang Schwede
Eckhard Ottow
Source :: Tetrahedron Letters. 34:5257-5260
Publication Year :: 1993
Publisher :: Elsevier BV, 1993.
Abstract: The synthesis of 11α-methyl-11β-(arylethynyl) substituted 19-norsteroids of 13, 14, and 15 is described. The preparation of these compounds opens for the first time an approach to 11-disubstituted antiprogestins.

Subjects :: chemistry.chemical_compound
chemistry
Estrane
medicine.medical_treatment
Organic Chemistry
Drug Discovery
Acetal
medicine
Propyne
Biochemistry
Combinatorial chemistry
Enone
Steroid

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