PARATHYROID HORMONE INTERFERES WITH THE MECHANOREGULATION OF BONE REMODELING

The human parathyroid peptide fragment hPTH 134 is an anabolic drug which, given intermittently, turns on bone remodeling by increasing bone formation. Its exact mode of action is however still unclear to date. In an earlier study, we found that in mechanically loaded animals, formation occurs preferentially at highly loaded areas, and resorption at lowly strained areas [1]. Here we investigate if and how PTH combined with mechanical loading alters the mechanoregulation of bone remodeling. With this, we aimed at a better understanding of the effectiveness of PTH in the treatment of bone diseases such as osteoporosis.