Utilization of Ki-67 and Phosphohistone-H3 in the Characterization of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential

Uterine smooth muscle tumors (USMT) are extremely common. The majority are benign leiomyomas (BLM) which pose little diagnostic difficulty. Leiomyosarcomas (LMS) exhibit frankly malignant features, making diagnosis similarly uncomplicated. A subset of USMT cannot be diagnosed unequivocally as BLM or LMS, thus are classified as smooth muscle tumors of uncertain malignant potential (STUMP). Diagnosis of STUMP is subjective, …