use of high-performance liquid chromatography technique for the simultaneous determination of amlodipine and valsartan

This technique was used in the estimation of amlodipine and valsartan simultaneously. The method was sensitive and accurate, and the estimation was done in a short time. In this work, a separation column of type L1, 150 mm was used to separate and sold. The group also found the ultraviolet spectrophotometer that used a wavelength of 239 nm, the temperature of the column was 40 degrees Celsius, and the mobile phase, consisting of 50:50 (acetonitrile: methanol: drops of triethylamine, pH = 2.4) was long. Through what was reached, we find that the method is sensitive, accurate and medium in size (101.43-99.13) and (100.17-99.53), and linear punches (6-14 mcg/ml) and (48-112 mcg/ml) for the two drugs, respectively. The method was applied to a number of pharmaceutical preparations available in the local market, successful in the real-time quantification of amlodipine and valsartan, respectively.