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Clinicopathological Significances of EZH2 & Twist-1 Combined Expressions in Renal Cell Carcinoma (RCC)
- Source :
- The Medical Journal of Cairo University. 86:2019-2028
- Publication Year :
- 2018
- Publisher :
- Egypts Presidential Specialized Council for Education and Scientific Research, 2018.
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Abstract
- Background: Renal cell carcinoma (RCC) is considered the commonest and most fatal malignant neoplasm of the kidney. Distant metastases are found in 30% of RCC patients at diagnosis, which is considered an important sign of predic-tion of patients' prognosis. So trying to clarify molecular mechanisms of metastases in RCC could help to discover a recent therapeutic target to decrease and control distant metastases and subsequently might improve patients prognosis.Aim of the Study: Was to assess the EZH2 & Twist-1 combined expressions in RCC tissues with different histopatho-logical subtypes and to correlate their expression with clin-icopathological parameters.Material and Methods: We have assessed expression of EZH2 & Twist-1 in tissue by using immunohistochemistry in 50 paraffin blocks of RCC different histopathological subtypes, analyzed correlations between the levels of combined expres-sions and clinicopthological data. Results: Increased EZH2 expression was positively asso-ciated with advanced AJCC stage, Lymph Node (L.N) metas-tases (p=0.006), higher grade (p
Details
- ISSN :
- 25369806
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- The Medical Journal of Cairo University
- Accession number :
- edsair.doi...........9f101f13303378c8684b15afdaea4280