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Improvement in glycemic level with saxagliptin in patients of type 2 diabetes mellitus who were previously on metformin monotherapy with uncontrolled diabetes
- Source :
- IP International Journal of Comprehensive and Advanced Pharmacology. 5:87-90
- Publication Year :
- 2020
- Publisher :
- IP Innovative Publication Pvt Ltd, 2020.
-
Abstract
- Introduction: Type 2 diabetes affects millions of people worldwide and significantly contributes to morbidity and mortality of those affected by it. Current guidelines recommend individualized treatment regimens following first line metformin therapy. Saxagliptin, a dipeptidyl-peptidase 4 inhibitor, provides a secondary mechanism of action to decrease hyperglycemia when used in combination with metformin. In this study we have tried to assess the efficacy of saxagliptin in patients of type 2 DM. Materials and Methods: A total of 35 patients were enrolled who were on metformin monotherapy and with uncontrolled diabetes. Patients were given saxagliptin 2.5 mg once a day. Patients were followed up at 1st, 3rd and 6th month and HbA1c, FPG and 2h-PG estimation was done during the follow up period. Results: The mean age SD in male and female patients was 61.42 yrs 6.99 and 55.93 yrs 5.74 respectively. The mean change in value from baseline at 24 weeks was 10.7%, 16.48% and 21.63% for HbA1c, FPG and 2h-PG respectively and 20% of patient had achieved HbA1c Conclusion: Saxagliptin has shown an improvement in glycemic index (HbA1c, FPG, 2h-PG) during 6 months of treatment in patients of type 2 DM. Keywords: Saxagliptin, Uncontrolled type 2DM, Efficacy.
- Subjects :
- medicine.medical_specialty
Clinical pharmacology
endocrine system diseases
business.industry
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
Type 2 diabetes
Saxagliptin
medicine.disease
law.invention
Metformin
chemistry.chemical_compound
Glycemic index
chemistry
law
Diabetes mellitus
Internal medicine
medicine
business
Glycemic
medicine.drug
Subjects
Details
- ISSN :
- 24569542 and 25815555
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- IP International Journal of Comprehensive and Advanced Pharmacology
- Accession number :
- edsair.doi...........9e8b6e66bf505fa968d5804ed00dbe82