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Stomatitis associated with mammalian target of rapamycin inhibition
- Source :
- The Journal of the American Dental Association. 149:291-298
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Background Patients with metastatic breast cancer may develop oral morbidities that result from therapeutic interventions. Mammalian target of rapamycin (mTOR) inhibitor–associated stomatitis (mIAS) is a common adverse event (AE), secondary to mTOR inhibitor therapy, that can have a negative impact on treatment adherence, quality of life, and health care costs. A multidisciplinary team approach is important to minimize mIAS and to maximize treatment benefits to patients with breast cancer. In this review, we discuss the pathophysiology, diagnosis, and natural history of mIAS. Current and new management strategies for the prevention and treatment of mIAS are described in the context of fostering a coordinated team care approach to optimizing patient care. Types of Studies Reviewed The authors conducted a PubMed search from 2007 through 2017 using the terms "stomatitis," "mIAS," "everolimus," "mTOR," "metastatic breast cancer," and "oral care." They selected articles published in peer-reviewed journals that reported controlled trials and evidence-based guidelines. Results mIAS can be distinguished from mucositis caused by cytotoxic chemotherapy or radiotherapy on the basis of cause, clinical presentation, and treatment paradigms. Specific preventive and therapeutic management strategies can be implemented across the continuum of patient oral health care. Practical Implications Oral health care providers are on the frontline of oral health care for patients with metastatic breast cancer and are uniquely positioned to provide patient education, advocate accurate reporting of mIAS, and support early identification, monitoring, and prompt intervention to mitigate the severity and duration of this manageable, potentially dose-limiting AE.
- Subjects :
- medicine.medical_specialty
Everolimus
business.industry
medicine.medical_treatment
medicine.disease
Metastatic breast cancer
Radiation therapy
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Breast cancer
030220 oncology & carcinogenesis
Health care
medicine
Mucositis
business
Intensive care medicine
Adverse effect
General Dentistry
medicine.drug
Patient education
Subjects
Details
- ISSN :
- 00028177
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- The Journal of the American Dental Association
- Accession number :
- edsair.doi...........9e8b0946d5344c546620001d1e303b33